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Updated: 21 May 2026

10 Best Acidophilus Supplements Softgel

#1 Best Pick
Thorne Research - FloraSport 20B Probiotic, 20 Billion Active Cultures per Capsule - 30 Capsules

Thorne Research - FloraSport 20B Probiotic, 20 Billion Active Cultures per Capsule - 30 Capsules

Brand: THORNE
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  • Immune: Perfect for individuals of all ages
  • FloraSport 20B is a blend of four probiotic strains โ€“ Lactobacillus paracasei and L. acidophilus, Bifidobacterium lactis, and Bacillus subtilis โ€“ in a stable, delayed-release capsule
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#2 Best Value
NOW 8 Billion Acidophilus & Bifidus,120 Veg Capsules

NOW 8 Billion Acidophilus & Bifidus,120 Veg Capsules

Brand: NOW
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  • PROMOTES POSITIVE PROBIOTIC BALANCE*: This product has a blend of the two prominent types of resident intestinal bacteria
  • REFRIGERATE TO MAINTAIN POTENCY: Regular intake of probiotics can aid in maintaining healthy intestinal flora* This product is formulated to deliver a potency of 8 billion CFU through the Best By date
  • STRAIN VERIFIED: The probiotic strains in this product have been identity-verified using DNA-fingerprinting technology
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
  • Packaged in the USA by a family owned and operated company since 1968
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#3 Budget Pick
Nutricost Lactobacillus Acidophilus 10 Billion Cfu, 120 Veggie Capsules - Positive Probiotic Balance

Nutricost Lactobacillus Acidophilus 10 Billion Cfu, 120 Veggie Capsules - Positive Probiotic Balance

Brand: Nutricost
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  • 10 Billion CFU In Every Capsule (120 Servings)
  • 120 Capsules Per Bottle
  • "Friendly" Bacteria For Healthy Intestinal Flora
  • Gluten Free and Non-GMO
  • Manufactured In a GMP Compliant, FDA Registered Facility
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#4 Top Choice
NOW Acidophilus/Bifidus 8 Billion, 60 Veg Capsules (Pack of 2)

NOW Acidophilus/Bifidus 8 Billion, 60 Veg Capsules (Pack of 2)

Brand: NOW
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  • Promotes Positive Probiotic Balance*
  • Take 1 capsule 1 to 2 times daily between meals or on an empty stomach. Refrigerate to maintain potency.
  • UL Dietary Supplement Certification;Keto-Friendly;GMP;Kosher (Triangle K);Non-GMO;Probiotic Strain Verified
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968
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#5 Popular Choice
Nutrition Now PB8 Pro-Biotic Vegetarian Acidophilus - 120 capsules per pack - 3

Nutrition Now PB8 Pro-Biotic Vegetarian Acidophilus - 120 capsules per pack - 3

Brand: Nutrition Now
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  • INCLUDES: 120 vegetarian capsules of Nutrition Now PB8 Probiotic
  • SUPPORTS: Digestive health
  • CONTAINS: 14 billion active cultures; 8 strains of beneficial probiotic
  • SAFE: Vegetarian formula; Contains no gluten, eggs, milk, peanuts, tree nuts, or soy
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#6 Top Pick
Puritan's Pride Nature's Promise Probiotic Supplement, Acidophilus, 250 Count

Puritan's Pride Nature's Promise Probiotic Supplement, Acidophilus, 250 Count

Brand: Puritan's Pride
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#7 Top Pick
NOW Acidophilus Two Billion,250 Capsules

NOW Acidophilus Two Billion,250 Capsules

Brand: NOW
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  • HEALTHY INTESTINAL FLORA*/PROMOTES POSITIVE PROBIOTIC BALANCE*: Lactobacillus acidophilus, one of the most prominent types of resident bacteria in the intestinal tract, has been used as a probiotic for decades.* Take 1 NOW Acidophilus Two Billion capsule 1 to 4 times daily between meals or on an empty stomach. Keep refrigerated to maintain potency.
  • STRAIN VERIFIED: Probiotic Strain Verified products are NOW probiotic products in which the probiotic strains have been analyzed and their identity verified using the cutting-edge RiboPrinter microbial characterization system. The Probiotic Strain Verified seal is your assurance that the bacterial strains in these NOW probiotic products have been verified using the latest analytical methods.
  • CLASSIFICATIONS/CERTIFICATIONS: Non-GMO, Strain Verified, Soy Free, Vegan/Vegetarian, Nut Free, Gluten Free, Corn Free, Dairy Free, Egg Free, Keto Friendly
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968
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#8 Top Pick
Vitamatic Acidophilus Probiotic - 10 Billion CFU - 5X Potency - Daily Probiotic Supplement, Supports Digestive Health - 120 Tablets

Vitamatic Acidophilus Probiotic - 10 Billion CFU - 5X Potency - Daily Probiotic Supplement, Supports Digestive Health - 120 Tablets

Brand: Vitamatic
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  • Probiotic supplement contains 10 billion CFUs of Lactobacillus acidophilus to support digestive and immune health*
  • Helps maintain a healthy balance of gut flora, supports digestive system function and promotes overall well-being
  • Gluten-free, vegan and non-GMO, with no artificial colors, flavors or sweeteners
  • Easy-to-take tablet with a convenient once-daily dose
  • Manufactured in a USA based cGMP-certified facility, ensuring quality and potency
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#9 Top Pick
Nature's Bounty Probiotic Acidophilus Tablets, 120 Count

Nature's Bounty Probiotic Acidophilus Tablets, 120 Count

Brand: Nature's Bounty
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  • Friendly Bacteria for the Digestive System*
  • 100 Million Organismsโ—Š
  • Lactobacillus Acidophilus
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#10 Top Pick
Probiotic Pearls Acidophilus Once Daily Probiotic Supplement, 1 Billion Live Cultures, Survives Stomach Acid, No Refrigeration, 90 Softgels (Packaging May Vary)

Probiotic Pearls Acidophilus Once Daily Probiotic Supplement, 1 Billion Live Cultures, Survives Stomach Acid, No Refrigeration, 90 Softgels (Packaging May Vary)

Brand: Nature's Way
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  • Probiotic Pearls Acidophilus contains 2 strains and 1 billion cultures in a convenient, once-daily softgel that's small and easy to swallow. This daily probiotic formula helps protect against occasional bloating, constipation and digestive discomfort.*
  • Taking Probiotic Pearls Acidophilus provides L. Acidophilus for the small intestine and B. Longum for the large intestine (colon) to help promote digestive balance and colon health and support immune health.*
  • Adults take 1 softgel daily. Small probiotic pearls are easy to swallow and conveniently sized to take anywhere and everywhere, with no refrigeration required.
  • Made with wholesome ingredients: Contains no salt, yeast-derived ingredients, wheat, or artificial colors.
  • Natureโ€™s Way is a trusted health partner that believes healthy starts inside, with supplements that provide digestive support.*
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