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Updated: 06 Apr 2026

10 Best Cold Sore Treatments

#1 Best Pick
Abreva 2grm Pump Size 1ct Abreva Cold Sore Treatment

Abreva 2grm Pump Size 1ct Abreva Cold Sore Treatment

Brand: Abreva
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  • wash hands before and after applying cream
  • apply to affected area on face or lips at the first sign of cold sore/fever blister (tingle)
  • early treatment ensures the best results
  • rub in gently but completely
  • use 5 times a day until healed; children under 12 years: ask a doctor
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#2 Best Value
Renew Actives MAXIMUM STRENGTH L-Lysine 1000mg Capsules w. Zinc & Vitamin C (RARE) - For Cold Sore Treatment to Help Prevent Herpes Simplex Virus (HSV) -Collagen for Hair, Skin & Nails - Easy to Swallow & Vegan - Made in Canada

Renew Actives MAXIMUM STRENGTH L-Lysine 1000mg Capsules w. Zinc & Vitamin C (RARE) - For Cold Sore Treatment to Help Prevent Herpes Simplex Virus (HSV) -Collagen for Hair, Skin & Nails - Easy to Swallow & Vegan - Made in Canada

Brand: Renew Actives
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  • ENCOURAGE NATURAL HEALING: By helping create collagen, l-lysine can help improve wound healing, reduce the duration and frequency of cold sores, and support the healthy formation of connective tissues.
  • IMPRESSIVE HEALTH BENEFITS: Lysine, like all amino acids, is a building block for protein in your body and l-lysine is the form your body is able to utilize to maintain overall health and wellness.
  • POWERFUL ANTIOXIDANT SUPPORT: L-Lysine with Zinc and Vitamin C is a rich source of antioxidants that can help protect your body against free radicals and reduce damage caused by oxidative stress.
  • MADE JUST FOR YOU: 1000mg L-Lysine Plus is formulated to be double the strength to help you maintain healthy skin and nails, connective tissues, blood vessels, bones, teeth, and immune system function.
  • RECOMMENDED DOSAGE: Adults over 18 may take one tablet, 1-3 times per day with food a few hours before or after taking other medications or natural health products; each bottle contains 60 tablets.
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#3 Budget Pick
How to get rid of a cold sore fast: Discover the best treatments for cold sores, antiviral remedies, supplements and diet to fight back

How to get rid of a cold sore fast: Discover the best treatments for cold sores, antiviral remedies, supplements and diet to fight back

Brand: Independently published
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#4 Top Choice
100% Natural Lip Balm 30ML Natural Cold Sore Prevention Treatment Moisturising Lip Balm Natural Ingredients Only - Lip Balm - Lip Repair - Lip Moisturiser Best Lip Balm For Cracked Lips MADE IN UK

100% Natural Lip Balm 30ML Natural Cold Sore Prevention Treatment Moisturising Lip Balm Natural Ingredients Only - Lip Balm - Lip Repair - Lip Moisturiser Best Lip Balm For Cracked Lips MADE IN UK

Brand: Ancient Chemistry
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  • 30ml of natural lip balm: moisturises the lips and is a treatment and prevention against cold sores in one. Made in the UK using only natural ingredients
  • Lip care: ideal for breathing new life into dry, dried and chapped lips. No alcohol, paraffin, petroleum jelly, parabens, phthalates or SLS.
  • 100% NATURAL INGREDIENTS: shea butter, olive oil, beeswax. Sweet Orange Essential Oil, Frankincense Essential Oil. As these ingredients are natural and edible, they can be applied completely safely in the mouth area.
  • Sweet Orange Lip Ointment Flavour Lip Balm: lip treatment and cold sore treatment, use it daily.
  • Healing Ointment for Lips: There are no chemicals, synthetic ingredients, artificial colours or perfumes. All packaging and products are plastic free and the product is natural, palm oil free and cruelty free.
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#5 Popular Choice
Nyal Nyal Cold Sore Crm Blister, 10 grams

Nyal Nyal Cold Sore Crm Blister, 10 grams

Brand: Nyal
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  • Nyal Cold Sore Cream provides soothing, healing, protective relief from the symptoms of cold sores and cracked lips
  • Brand: Nyal
  • Size: 10 g
  • Lip Care
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#6 Top Pick
Betadine Cold Sore Ointment, Treatment of Cold Sores, 7.5g

Betadine Cold Sore Ointment, Treatment of Cold Sores, 7.5g

Brand: Betadine
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  • Betadine Cold Sore Ointment is recommended to help with the treatment of cold sores
  • If applied at the first signs of a cold sore (usually a tingling or itching sensation), this ointment can help to slow the progress of infection
  • Cold Sore Ointment can help reduce the risk of spreading the infection
  • The convenient tube makes the ointment easy to apply
  • Always read the label; Follow the directions for use; If symptoms persist, talk to your health professional; Betadine is a registered trademark of Mundipharma AG, used under license
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#7 Top Pick
Healthy Care Super Lysine Cold Sore Relief Tablets - Reduce Symptoms of Cold Sores & Promotes Immune Function - Supports Skin Health - Premium Quality Dietary Supplement - 100 Tablets - 1000 mg

Healthy Care Super Lysine Cold Sore Relief Tablets - Reduce Symptoms of Cold Sores & Promotes Immune Function - Supports Skin Health - Premium Quality Dietary Supplement - 100 Tablets - 1000 mg

Brand: Healthy Care
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  • Rapid relief: Healthy Care super lysine cold sore relief is specifically formulated with a high-strength dose of lysine, an essential amino acid, to effectively manage and reduce the symptoms of facial cold sores. Enhanced with vitamin C and zinc, this supplement is designed to strengthen immune defences and skin health.
  • Health benefits: This lysine supplement not only aims to lessen the severity and occurrence of cold sores but also supports collagen production for skin health and accelerates wound healing. The added zinc promotes robust immune function, and the antioxidant properties of vitamin C help reduce oxidative pressure.
  • Convenient tablet form: The product is conveniently packaged in tablet form, making it easy to consume on a daily basis. Each tablet is crafted to be easy to swallow and is formulated without added sugars, yeast, lactose, gluten, salt, or any artificial colours and flavours, catering to a wide range of dietary needs and preferences.
  • Clean and pure: Free from added sugar, yeast, gluten, salt, artificial colours, and preservatives, these lysine tablets are an excellent choice for individuals looking for a pure supplement option. This commitment to purity makes them suitable for a wide range of dietary preferences and sensitivities.
  • Quality first: Australia is one of the few countries in the world that regulates health supplements with therapeutic regulations. Before anything leaves our warehouse it has to go through over 20 quality checks. All conforming to the TGA and cGMP standards.
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#8 Top Pick
Zovirax, Anti-Viral Cold Sore Cream Pump, Treatment for Cold Sores, Aciclovir 5%, 2g

Zovirax, Anti-Viral Cold Sore Cream Pump, Treatment for Cold Sores, Aciclovir 5%, 2g

Brand: Zovirax
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  • Zovirax Cold Sore Treatment cuts cold sore healing time in half compared with no treatment. **On average compared with historical data for untreated cold sores
  • Contains the anti-viral agent, aciclovir 5%, that inhibits the multiplication of the cold sore virus
  • Zovirax MAC-P penetrating formula gets to the site of infection
  • Available in a tube or pump for a clean, controlled application
  • Easy rub-in formula: with dimethicone that disappears quickly into the skin
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#9 Top Pick
Compeed Cold Sore Discreet Healing Patch, 15 Patches, Cold Sore Treatment, More Convenient than Cold Sore Creams, Dimensions: 1.5cmx1.5cm

Compeed Cold Sore Discreet Healing Patch, 15 Patches, Cold Sore Treatment, More Convenient than Cold Sore Creams, Dimensions: 1.5cmx1.5cm

Brand: Compeed
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  • FAST HEALING: ultra-thin hydrocolloid gel provides a moist environment to help reduce scab formation
  • ACT LIKE A SHIELD: provides a protective barrier against external environment, helping to reduce the risk of contamination
  • STAYS IN PLACE UP TO 12 HOURS AND DISCREET: adhesive, tapered edges so Compeed flexes with movement, and translucent patch blends in with the skin
  • STARTS TO WORK from the very first sign and continues throughout all stages
  • NEW APPLICATOR : to improve ease of application. Tip: try not to press on circular section of green tab when preparing to apply
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#10 Top Pick
Zovirax Antiviral Cold Sore Treatment Cream Tube, 2g | Aciclovir 5% w/w

Zovirax Antiviral Cold Sore Treatment Cream Tube, 2g | Aciclovir 5% w/w

Brand: Zovirax
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  • Contains the anti-viral agent, aciclovir 5 percent, that inhibits the multiplication of the cold sore virus
  • Zovirax MAC-P penetrating formula gets to the site of infection to speed healing and get rid of cold sores
  • Available in a tube or pump for a clean, controlled application
  • Easy rub-in formula: with dimethicone that disappears quickly into the skin
  • Cuts healing time in half compared with no cold sore treatment (On average: compared with historical data for untreated cold sores)
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