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Updated: 08 Oct 2025

10 Best Dog Flea And Tick Medications

#1
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Arava Flea & Tick Prevention Collar - for Dogs & Puppies - Length-25'' - 11 Natural Active Ingredients - Safe for Babies & Pets - Safely Repels Pests - Enhanced Control & Defense - 5 Months Protection

Brand: Arava - Dead Sea Pet Spa
$80.13
⭐ 4.7
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    No features listed
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#2
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FRONTLINE SPRAY 250ML

Brand: Frontline
$59.99 ($30.00 / 100
⭐ 4.7
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    Flea and tick treatment spray that is ideal for both cats and dogs
  • Use to control fleas every 2-12 weeks
  • Controls brown ticks when applied monthly and paralysis ticks when applied every 3 weeks
  • Helps to control flea allergy dermatitis
  • Safe to use on puppies and kittens from 2 days old
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#3
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bogaprotect Spot On Dog - Flea and Tick Protection for Dogs - 1-4 kg - Tick Remedy for Dogs - Natural Tick Protection for Dogs - UBO0350 - Supply for 12 Weeks

Brand: bogaprotect
$29.65
⭐ 4.7
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    Long-lasting protection effect the 3 tubes included offer enough supply for up to 12 weeks. Thanks to the easy application, the spot on for dogs is quickly applied, so that your four-legged friend can devote itself to the fun things again
  • Effective preventative without killing Our EC oil has a unique production process that mimics natural leaf ageing. The anti-tick agent in dogs repels ticks without killing the ticks or fleas
  • Active ingredient on plant-based the bogaprotect anti-tick agent is an oil from the leaves of the lemon eucalyptus tree. This unique blend of at least 23 plant components offers excellent insect repellent properties
  • Clinically tested and proven the effectiveness of bogaprotect flea and tick protection has been tested and proven in a comparison field study, in a simulated application test under real conditions. Trust bogaprotect Spot-On!
  • No resistance formation possible since the active ingredient is our spot-on plant based, resistance formation is not possible. The individual components even enhance the effectiveness of each other. The natural dog flea and tick protection
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#4
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Apex Plus Flea and Tick Prevention for Dogs | X-Large (89-132 lbs) | 3-Month Supply | Dog Flea and Tick Treatment | 24-Hour Activation, Waterproof, 30-Day Protection

Brand: APEX ANIMAL HEALTH
$43.81 ($14.60 / cou
⭐ 5
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    EFFECTIVE DOG FLEA & TICK CONTROL Apex Plus flea and tick prevention for dogs kills adult fleas and also targets flea eggs, larvae, and prevents the development of flea pupae, ensuring a thorough elimination of fleas at all life stages. With tailored formulations for dogs weighing 5-22 lbs (Small), 23-44 lbs (Medium), 45-88 lbs (Large), and 89-132 lbs (X-Large), Apex Plus dog flea medicine offers a customized solution for various sizes, providing precise and effective protection.
  • CIRCUMSTANCES FOR TREATMENT Extra large dog flea treatment deals with addressing an existing infestation. When you're treating dog fleas or ticks, you're typically aiming to eliminate the parasites that are already present on the animal's body. Severe infestations may require veterinary input for effective treatment and subsequent preventative measures.
  • CIRCUMSTANCES FOR PREVENTION Extra large dog tick prevention focuses on keeping the infestation from occurring in the first place. Preventive measures are aimed at stopping the parasites from ever becoming a problem. Dog flea and tick prevention is proactive and aims to keep the parasites away before they become an issue.
  • INSECT GROWTH REGULATOR (IGR) ADVANTAGE The inclusion of (S)-methoprene as an IGR sets Apex Plus dog flea treatment apart by preventing flea eggs from hatching and interrupting the insect's life cycle, enhancing the product's efficacy in controlling infestations. The combination of Fipronil and (S)-methoprene works synergistically to attack the nervous systems of fleas and ticks while inhibiting the maturation of flea eggs and larvae, effectively breaking the flea life cycle.
  • TOPICAL APPLICATION THAT'S SAFE FOR YEAR-ROUND USE Apex Plus topical flea treatment for dogs is easy to apply, making the treatment process convenient for pet owners. The product is dispersed over the pet's body by natural skin oils, ensuring even coverage. Designed for monthly application, Apex Plus flea medication for dogs provides a year-round repellent against fleas and ticks, maintaining the health and well-being of your pet.
  • LONG-LASTING WATERPROOF PROTECTION FORMULA A single application of this flea medicine for dogs provides 30 days of continuous protection against fleas, ticks, and chewing lice, offering a hassle-free solution for pet owners. Apex Plus flea prevention for dogs becomes waterproof just 24 hours after application, ensuring efficacy even if your dog gets wet. This feature adds convenience for pet owners dealing with active dogs or living in rainy climates.
  • THE VALUE YOUR PET DESERVES Comprehensive and clear user guidelines are provided for each weight range, addressing common concerns such as bathing, application frequency, and potential interactions, ensuring pet owners have the safety and reliability information they need for proper use.
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#5
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FRONTLINE SPRAY 100ML

Brand: Frontline
$38.09
⭐ 4.8
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    Flea and tick treatment spray that is ideal for both cats and dogs
  • Use to control fleas every 2-12 weeks
  • Controls brown ticks when applied monthly and paralysis ticks when applied every 3 weeks
  • Helps to control flea allergy dermatitis
  • Safe to use on puppies and kittens from 2 days old
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#6
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FRONTLINE PLUS DOG 40-60KG X/LGE 3'S RED

Brand: Frontline Plus
$72.80 ($24.27 / cou
⭐ 4.1
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    A powerful protection against fleas and ticks
  • Rapidly kills fleas and eliminates 98 percent of fleas within 24 hours of application
  • Breaks flea life cycle and prevents re-infestation
  • Treats and prevents flea allergy dermatitis
  • Controls biting lice on dogs and puppies
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#7
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FRONTLINE PLUS DOG 0-10KG SMALL 6'S ORANGE

Brand: Frontline
$52.99 ($8.83 / coun
⭐ 4.7
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    A powerful protection against fleas and ticks
  • Rapidly kills fleas and eliminates 98 percent of fleas within 24 hours of application
  • Breaks flea life cycle and prevents re-infestation
  • Treats and prevents flea allergy dermatitis
  • Controls biting lice on dogs and puppies
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#8
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FRONTLINE PLUS DOG 20-40KG LGE 3'S PURPLE

Brand: Frontline Plus
$41.99 ($14.00 / cou
⭐ 4.7
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    A powerful protection against fleas and ticks
  • Rapidly kills fleas and eliminates 98 percent of fleas within 24 hours of application
  • Breaks flea life cycle and prevents re-infestation
  • Treats and prevents flea allergy dermatitis
  • Controls biting lice on dogs and puppies
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#9
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NEOVET FOR DOGS (OVER 25KG) 6 PACK

Brand: Neovet
$58.59 ($9.76 / coun
⭐ 4.6
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    Kills flea larvae in pet surroundings
  • Controls roundworm, hookworm and whipworm
  • Controls sarcoptic mange and ear mites
  • Suitable for pets sensitive skin
  • Kills fleas on contact BEFORE they bite your pet
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#10
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NEOVET FOR DOGS (4 - 10KG) 6 PACK

Brand: Neovet
$40.79
⭐ 4.2
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    Multi-parasite prevention treatment
  • Protects against most major intestinal worms
  • Eradicates fleas, flea larvae, sarcoptic mange and mites
  • Protect against heartworm
  • Eliminates roundworms, hookworms and whipworms
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