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Updated: 06 Apr 2026

10 Best Serial Port Cards

#1 Best Pick
StarTech.com PEX2S953LP 2 Port RS232 PCIe Serial Adapter Card with 16950 UART

StarTech.com PEX2S953LP 2 Port RS232 PCIe Serial Adapter Card with 16950 UART

Brand: StarTech
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  • Compatible with industry standard 16950 UART
  • Supports max baud rate of up-to 921.4Kbps
  • Provides 5/12V power output on Pin 9 when external power is connected
  • 256-byte depth FIFO per transmitter and receiver
  • Supports 9, 8, 7, 6, 5 data bits
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#2 Best Value
34mm Express Card to Serial Port DB9 COM RS232 RS-232 Cable Expansion Card for Laptop

34mm Express Card to Serial Port DB9 COM RS232 RS-232 Cable Expansion Card for Laptop

Brand: MEO
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  • Compatible with standard 34mm Express Card slot
  • Compliant with standard RS-232 serial port
  • System Requirements: Windows 98SE, ME, 2000, XP, Vista, Windows 7
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#3 Budget Pick
Syba Dual Port Serial DB9 RS232 PCIe X1 Card Components SD-PEX15022

Syba Dual Port Serial DB9 RS232 PCIe X1 Card Components SD-PEX15022

Brand: Syba
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  • Fully compliant with PCI-Express base Specification Revision 1.0A
  • Chipset: MCS9922
  • Included Low profile bracket
  • Compatible with industrial standard 16C550 UART
  • On chip 256-byte depth FIFO in transmit.Form Factor: Low-profile
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#4 Top Choice
ELIATER PCIE 2 Port Serial Expansion Card PCI Express to Industrial DB9 RS232 COM Port Adapter WCH382 Chip for Desktop PC with Low Bracket

ELIATER PCIE 2 Port Serial Expansion Card PCI Express to Industrial DB9 RS232 COM Port Adapter WCH382 Chip for Desktop PC with Low Bracket

Brand: ELIATER
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  • This card capability allow for upgrade with additional serial cards to your computer easily. Note: Open the "CH38XDRV"file in the CD to install.
  • 2 x 16C550 Fast Uart serial ports, supporting data transfer rates up to 230400Bps.
  • Plug and Play, Automatically selects IRQ & IO address, Supports IRQ sharing.
  • Compliant with ExpressCard/34mm Standard; Compatible to 1-Lane (x1) PCI-Express Throughput.
  • Operating System: Windows 32bit 2000/XP/2003 Server/Vista and 64bit XP/2003 Server/Vista/WIN7/WIN8/WIN10/WIN11/Linux. (If there was any problem with PCIE 2 port serial expansion card, pls feel free to contact us, we will provide a solution within 24hrs.)
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#5 Popular Choice
PCI-E to USB3.0 Expansion Serial Card Adapter with Front 19PIN Interface, 2 Ports Desktops Card Support for XP 32/64 for 7 8 10, PCIE Card Super Speed Up to 5Gbps

PCI-E to USB3.0 Expansion Serial Card Adapter with Front 19PIN Interface, 2 Ports Desktops Card Support for XP 32/64 for 7 8 10, PCIE Card Super Speed Up to 5Gbps

Brand: Dpofirs
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  • Wide Operating System Compatibility: The expansion card is compatible with a range of operating systems, including XP 32/64, 7 32/64, 8, 8.1, and 10.
  • Performance and Functionality: The USB 3.0 expansion card is known for its performance and functionality.
  • Easy Installation Process: The USB 3.0 expansion card is designed for easy installation, making it convenient for users to upgrade their system without hassle.
  • High Speed Data Transfer Rates: The USB 3.0 expansion card supports transfer rates of up to 5 Gbps, enabling fast and efficient data transfer.
  • Bus Mode and Slot Compatibility: The expansion card operates in PCI-E x1 bus mode, providing compatibility with PCI-E x1, x4, x8, and x16 slots.
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#6 Top Pick
PCIe Serial Card, PCI Express RS232 Serial Adapter Card, 2 Port PCIe Serial Expansion Card for for Linux, AX99100 Chipset

PCIe Serial Card, PCI Express RS232 Serial Adapter Card, 2 Port PCIe Serial Expansion Card for for Linux, AX99100 Chipset

Brand: Jectse
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  • Full Duplex Channel: 2.5Gbps PCIE bus supporting full duplex channel. Compliant with Single Lane (x1) PCIExpress Specification Revision 1.0a.
  • Interface Slots: PCI Express x1 interface (also for PCIE x1, x4, x8, x16 slots). Two 9 pin RS 232 serial ports.
  • Support System: PCIE serial card supports operating systems for for for for , for XP, for 2000, for Linux, for DOS, for Server 2003.
  • AX99100 Chip: Allows to easily connect more serial devices to your computer. Stable and chipset AX99100 with enhancement chip. Supports remote wake up and power management functions.
  • Application Areas: Serially connected equipment, serial net/monitoring equipment, data acquisition system POS terminals and industrial PCs, I/O expansion of embedded systems.
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#7 Top Pick
StarTech 2-Port PCI Express Serial Card with 16C1050 UART - RS232 [PEX2S1050]

StarTech 2-Port PCI Express Serial Card with 16C1050 UART - RS232 [PEX2S1050]

Brand: StarTech
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  • MEETS INDUSTRY STANDARDS: The 2-port PCI express serial card is compliant with PCI Express 1.0a specification, and it's compatible with 1x, 2x, 4x, 8x and 16x PCI Express slots.
  • MAXIMUM COMPATIBILITY: The dual port DB9 to PCIe adapter is ideal for system upgrades in a wide range of applications including manufacturing equipment, POS equipment, and security devices.
  • HIGH-PERFORMANCE COMMUNICATION: The low-profile serial card delivers high-performance serial communication, with support for data transfer rates of up to 460Kbps.
  • SIMPLE INSTALLATION: The PCI dual serial adapter features IRQ sharing and supports plug-and-play connection. It has a standard-profile bracket installed, and an optional low-profile bracket.
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#8 Top Pick
Eacam PCIe RS232 Card, Dual Port PCI Express RS232 DB9 Serial Port Card, PCIe Serial Expansion Card for, Linux, Support POS Systems, Security Systems, Scanners

Eacam PCIe RS232 Card, Dual Port PCI Express RS232 DB9 Serial Port Card, PCIe Serial Expansion Card for, Linux, Support POS Systems, Security Systems, Scanners

Brand: Eacam
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  • [Expand Your Connectivity] Add two rs232 bd9 serial ports to desktop computers or industrial equipment through the pcie slot, supporting x1, x4, x8, x16 slots.
  • [Universal Compatibility] Full-size bracket suitable for standard pcs, for various applications in industries, logistics, and retail sectors.
  • [Driver Compatibility] Requires driver installation for xp, vista, 7, 8.x, 10, 11 and reference to compiled source code for linux kernel 2.6.x, 3.x, 4.x, 5.x systems.
  • [Versatile Applications] Seamlessly connect pos systems, industrial devices, security systems, scanners, printers, and more with this pcie serial expansion card.
  • [high speed Data Transfer] Asix ax99100 chip offers 256 byte depth fifo transfers, ensuring efficient data processing for and arm hardware platforms.
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#9 Top Pick
ECSiNG Port Card PCI Express Serial Card PCI Express Serial Extension Adapter PCI-E to RS232 Serial Expansion Card Compatible with Windows XP/Vista/7/8

ECSiNG Port Card PCI Express Serial Card PCI Express Serial Extension Adapter PCI-E to RS232 Serial Expansion Card Compatible with Windows XP/Vista/7/8

Brand: ECSiNG
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  • Dual RS232 Ports: Transform a single PCI Express slot into two RS232 (DB9) serial ports, doubling your connectivity options.
  • Compliance & Support: Conforms to PCI-Express Specification Revision 1.1. Supports DOS, Compatible with Windows 8/7/Vista/XP/2000/Server 2003-2008 32/64-bit, Compatible with Linux, and other operating systems.
  • Enhanced Data Transfer: Built-in 256-byte FIFO and hardware/software flow control ensure reliable data transfer at speeds of up to 250Kbps per port.
  • Simple Installation: Easy setup - just insert the PCI Express control card into the free slot on your computer and install the provided drivers.
  • Broad Utility: Perfectly suited for use in ticket printing, barcode scanning, card reading, cash register systems, and various other applications.
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#10 Top Pick
StarTech.com PEX2S953LP 2 Port RS232 PCIe Serial Adapter Card with 16950 UART

StarTech.com PEX2S953LP 2 Port RS232 PCIe Serial Adapter Card with 16950 UART

Brand: StarTech
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  • Compatible with industry standard 16950 UART
  • Supports max baud rate of up-to 921.4Kbps
  • Provides 5/12V power output on Pin 9 when external power is connected
  • 256-byte depth FIFO per transmitter and receiver
  • Supports 9, 8, 7, 6, 5 data bits
Check latest price on Amazon

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